Sinkholes and other karst structures in settled carbonate lands can be a significant source of hazard for humans and human works. Acque Albule, the study area of this work, is a Plio-Pleistocene basin near Rome, central Italy, superficially filled by a large and thick deposit of late Pleistocene thermogene travertine. Human activities blanket large portions of the flat territory covering most evidence from geological surface processes and potentially inducing scientists and public officials to underestimate some natural hazards including those connected with sinkholes. To contribute to the proper assessment of these hazards, a geomorphologic study of the basin was performed using digital elevation models (DEMs), recent aerial photographs, and field surveys. Historical material such as old aerial photographs and past geomorphologic studies both pre-dating the most part of quarrying and village building was also used together with memories of the elderly population. This preliminary study pointed out the presence of numerous potentially active sinkholes that are at present largely masked by either quarrying or overbuilding. Where this first study pointed out the apparent absence of sinkholes in areas characterized by high density of buildings, a detailed subsurface study was performed using properly-calibrated electrical resistivity tomography (ERT) and dynamic penetration measurements (DPSH), together with some borehole logs made available from the local municipality. This second study highlighted the presence of sinkholes and caves that are, this time, substantially hidden to the resolution of standard methods and materials such as aerial photographs, DEMs, and field surveys. Active sinkhole subsidence in the Acque Albule Basin may explain, at least in part, the frequent damages that affect numerous buildings in the area. The main conclusion from this study is that the mitigation of sinkhole hazard in highly populated areas has to pass through a thorough search of (hidden) sinkholes that can be masked by the Anthropocenic molding and blanketing of the territory. For these purposes, data from historical (pre-Anthropocene) documents as well as, where possible, subsurface investigations are fundamental.